Graves disease: Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland ( hyperthyroidism ).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy , antithyroid drugs, and/or thyroid surgery.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
5575 |
4. Check minimum number of eventsNone |
5575 |
5. Include endpointsNone |
5575 |
6. Filter based on genotype QC (FinnGen only) |
5366 |
Control definitions (FinnGen only)
Control exclude
E4_THYROID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E05
Name in latin
Thyreotoxicosis cum struma diffusa
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis with diffuse goitre
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 38371 | 31186 | 6900 |
| Only index persons | 35764 | 29429 | 6335 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.76 | 0.89 | 0.19 |
| Only index persons | 0.93 | 1.08 | 0.24 |
| Median age at first event (years) | |||
| Whole population | 49.44 | 49.13 | 51.36 |
| Only index persons | 48.69 | 48.33 | 50.36 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5366 | 4505 | 861 |
| Unadjusted period prevalence (%) | 1.55 | 1.77 | 0.43 |
| Median age at first event (years) | 49.27 | 48.32 | 54.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXGOITDIF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITDIF | 1.072 [0.97, 1.19] | 0.195 |
| Birth year | 0.998 [0.99, 1.01] | 0.668 |
During the follow-up period (1.1.1998 — 31.12.2019), 2220 out of 23978 females with E4_THYTOXGOITDIF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITDIF | 1.256 [1.11, 1.42] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 772 out of 5286 males with E4_THYTOXGOITDIF died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXGOITDIF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | 0.248% |
| 5 | 0.717% | 1.366% |
| 10 | 1.728% | 3.515% |
| 15 | 3.315% | 6.757% |
| 20 | 5.89% | 11.323% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXGOITDIF – Thyrotoxicosis with diffuse goitre
GWS hits: 23
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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