No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
10171 |
6. Filter based on genotype QC (FinnGen only) |
9801 |
Control definitions (FinnGen only)
Control exclude
THYROID_DISORDER_IBD
Extra metadata
First used in FinnGen datafreeze
DF2
Thyrotoxicosis
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 77269 | 61676 | 14979 |
| Only index persons | 67659 | 54737 | 12922 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.50 | 1.77 | 0.42 |
| Only index persons | 1.72 | 2.01 | 0.49 |
| Median age at first event (years) | |||
| Whole population | 54.48 | 53.92 | 57.07 |
| Only index persons | 52.97 | 52.26 | 55.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 9801 | 7771 | 2030 |
| Unadjusted period prevalence (%) | 2.63 | 3.05 | 1.02 |
| Median age at first event (years) | 52.41 | 50.56 | 59.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint THYROTOXICOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| THYROTOXICOSIS | 1.218 [1.12, 1.33] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.103 |
During the follow-up period (1.1.1998 — 31.12.2019), 6988 out of 42750 females with THYROTOXICOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| THYROTOXICOSIS | 1.423 [1.28, 1.58] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 2308 out of 10455 males with THYROTOXICOSIS died.
Mortality risk
Mortality risk for people of age
years, who have THYROTOXICOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.107% | 0.312% |
| 5 | 0.702% | 1.743% |
| 10 | 1.649% | 4.371% |
| 15 | 3.151% | 8.243% |
| 20 | 5.552% | 13.497% |
Relationships between endpoints
↥Index endpoint: THYROTOXICOSIS – Thyrotoxicosis
GWS hits: 30
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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