Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
277 |
4. Check minimum number of eventsNone |
277 |
5. Include endpointsNone |
277 |
6. Filter based on genotype QC (FinnGen only) |
273 |
Control definitions (FinnGen only)
Control exclude
THYROTOXICOSIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E05
Name in latin
Thyreotoxicosis cum struma uninodulari
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis with toxic single thyroid nodule
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2093 | 1687 | 393 |
| Only index persons | 1884 | 1532 | 352 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.01 |
| Only index persons | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.27 | 53.98 | 60.60 |
| Only index persons | 53.93 | 52.58 | 59.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 273 | 226 | 47 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.02 |
| Median age at first event (years) | 52.10 | 49.35 | 65.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXNOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXNOD | 1.287 [1.09, 1.53] | 0.004 |
| Birth year | 0.996 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 211 out of 1340 females with E4_THYTOXNOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXNOD | 1.204 [0.89, 1.62] | 0.223 |
| Birth year | 0.987 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 290 males with E4_THYTOXNOD died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXNOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.172% | 0.275% |
| 5 | 0.855% | 1.442% |
| 10 | 2.072% | 3.605% |
| 15 | 3.994% | 6.787% |
| 20 | 6.997% | 11.648% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXNOD – Thyrotoxicosis with toxic single thyroid nodule
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data