No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
5575 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2279 |
4. Check minimum number of eventsNone |
2279 |
5. Include endpointsNone |
2279 |
6. Filter based on genotype QC (FinnGen only) |
2190 |
Control definitions (FinnGen only)
Control exclude
AUTOIMMUNE
Control conditions
not E4_THYTOXGOITDIF
Extra metadata
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Autoimmune hyperthyroidism
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis with diffuse goitre
- Thyrotoxicosis, other and/or unspecified
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 14824 | 11965 | 2766 |
| Only index persons | 14358 | 11690 | 2668 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.34 | 0.08 |
| Only index persons | 0.37 | 0.43 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 50.67 | 50.39 | 52.43 |
| Only index persons | 50.46 | 50.13 | 51.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2190 | 1819 | 371 |
| Unadjusted period prevalence (%) | 0.62 | 0.71 | 0.19 |
| Median age at first event (years) | 50.46 | 49.44 | 55.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AUTOIMMUNE_HYPERTHYROIDISM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AUTOIMMUNE_HYPERTHYROIDISM | 1.083 [0.97, 1.21] | 0.162 |
| Birth year | 0.998 [0.99, 1.01] | 0.617 |
During the follow-up period (1.1.1998 — 31.12.2019), 1133 out of 10957 females with AUTOIMMUNE_HYPERTHYROIDISM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AUTOIMMUNE_HYPERTHYROIDISM | 1.223 [1.05, 1.42] | 0.008 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 392 out of 2528 males with AUTOIMMUNE_HYPERTHYROIDISM died.
Mortality risk
Mortality risk for people of age
years, who have AUTOIMMUNE_HYPERTHYROIDISM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.217% |
| 5 | 0.744% | 1.299% |
| 10 | 1.652% | 3.238% |
| 15 | 3.454% | 6.115% |
| 20 | 6.064% | 10.044% |
Relationships between endpoints
↥Index endpoint: AUTOIMMUNE_HYPERTHYROIDISM – Autoimmune hyperthyroidism
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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