≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Thyrotoxicosis with toxic multinodular goitre

DOID EFO Endpoint Browser PheWeb

E4_THYTOXGOITMULT

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E05.2
  • Hospital discharge: ICD-9 — 2422
  • Hospital discharge: ICD-8 — 2421
  • Cause of death: ICD-10 — E05.2
  • Cause of death: ICD-9 — 2422
  • Cause of death: ICD-8 — 2421

2 out of 7 registries used, show all original rules.

1944

4. Check minimum number of events

None

1944

5. Include endpoints

None

1944

6. Filter based on genotype QC (FinnGen only)

1885

Control definitions (FinnGen only)

Control exclude THYROTOXICOSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E05
Name in latin Thyreotoxicosis cum struma multinodulari

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 18329 15393 2783
Only index persons 14535 12435 2100
Unadjusted period prevalence (%)
Whole population 0.38 0.44 0.08
Only index persons 0.40 0.46 0.08
Median age at first event (years)
Whole population 60.94 60.51 63.51
Only index persons 60.38 59.55 65.30

-FinnGen-

Key figures

All Female Male
Number of individuals 1885 1524 361
Unadjusted period prevalence (%) 0.52 0.60 0.18
Median age at first event (years) 60.64 59.04 67.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYTOXGOITMULT and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYTOXGOITMULT 1.258 [1.14, 1.39] < 0.001
Birth year 0.995 [0.99, 1.0] 0.248

During the follow-up period (1.1.1998 — 31.12.2019), 1886 out of 8353 females with E4_THYTOXGOITMULT died.

Males

Parameter HR [95% CI] p-value
E4_THYTOXGOITMULT 1.226 [1.04, 1.45] 0.016
Birth year 0.988 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 410 out of 1483 males with E4_THYTOXGOITMULT died.

Mortality risk

Mortality risk for people of age

years, who have E4_THYTOXGOITMULT.

N-year risk Females Males
1 0.142% 0.251%
5 0.77% 1.437%
10 1.909% 3.544%
15 3.56% 6.687%
20 6.338% 11.5%

Relationships between endpoints

↥

Index endpoint: E4_THYTOXGOITMULT – Thyrotoxicosis with toxic multinodular goitre

GWS hits: 16

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data