Toxic Nodular Goiter: Nodular enlargement of the thyroid gland associated with hyperthyroidism.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1944 |
4. Check minimum number of eventsNone |
1944 |
5. Include endpointsNone |
1944 |
6. Filter based on genotype QC (FinnGen only) |
1885 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Thyrotoxicosis with toxic multinodular goitre based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 18329 | 15393 | 2783 |
Only index persons | 14535 | 12435 | 2100 |
Unadjusted period prevalence (%) | |||
Whole population | 0.38 | 0.44 | 0.08 |
Only index persons | 0.40 | 0.46 | 0.08 |
Median age at first event (years) | |||
Whole population | 60.94 | 60.51 | 63.51 |
Only index persons | 60.38 | 59.55 | 65.30 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 1885 | 1524 | 361 |
Unadjusted period prevalence (%) | 0.52 | 0.60 | 0.18 |
Median age at first event (years) | 60.64 | 59.04 | 67.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXGOITMULT and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
E4_THYTOXGOITMULT | 1.258 [1.14, 1.39] | < 0.001 |
Birth year | 0.995 [0.99, 1.0] | 0.248 |
During the follow-up period (1.1.1998 — 31.12.2019), 1886 out of 8353 females with E4_THYTOXGOITMULT died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
E4_THYTOXGOITMULT | 1.226 [1.04, 1.45] | 0.016 |
Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 410 out of 1483 males with E4_THYTOXGOITMULT died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXGOITMULT.N-year risk | Females | Males |
---|---|---|
1 | 0.142% | 0.251% |
5 | 0.77% | 1.437% |
10 | 1.909% | 3.544% |
15 | 3.56% | 6.687% |
20 | 6.338% | 11.5% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXGOITMULT – Thyrotoxicosis with toxic multinodular goitre
GWS hits: 16