No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
7709 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
3572 |
6. Filter based on genotype QC (FinnGen only) |
3437 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF7
Similar endpoints
↥List of similar endpoints to
Graves disease, strict definition
based on the number of shared cases.
Similar with more cases:
- Carbimazole or st.post thyroidectomy, condition for graves disease
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23064 | 18836 | 4057 |
| Only index persons | 22484 | 18513 | 3971 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.46 | 0.54 | 0.11 |
| Only index persons | 0.59 | 0.68 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 49.31 | 49.21 | 50.36 |
| Only index persons | 49.26 | 49.12 | 49.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3437 | 2917 | 520 |
| Unadjusted period prevalence (%) | 1.01 | 1.15 | 0.26 |
| Median age at first event (years) | 49.62 | 48.91 | 53.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_GRAVES_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_STRICT | 1.07 [0.94, 1.22] | 0.294 |
| Birth year | 0.992 [0.98, 1.0] | 0.082 |
During the follow-up period (1.1.1998 — 31.12.2019), 1142 out of 16342 females with E4_GRAVES_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_STRICT | 1.036 [0.89, 1.21] | 0.654 |
| Birth year | 0.991 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 345 out of 3489 males with E4_GRAVES_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have E4_GRAVES_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.062% | 0.176% |
| 5 | 0.599% | 1.156% |
| 10 | 1.414% | 3.262% |
| 15 | 2.705% | 6.508% |
| 20 | 4.747% | 11.059% |
Relationships between endpoints
↥Index endpoint: E4_GRAVES_STRICT – Graves disease, strict definition
GWS hits: 14
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data