No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
811 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
792 |
4. Check minimum number of eventsNone |
792 |
5. Include endpointsNone |
792 |
6. Filter based on genotype QC (FinnGen only) |
761 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF7
Similar endpoints
↥List of similar endpoints to
Graves ophthalmopathy
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system and orbit in diseases classified elsewhere
- Disorders of orbit
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Disorders of eyelid, lacrimal system and orbit
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4440 | 3590 | 832 |
| Only index persons | 4309 | 3510 | 799 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.02 |
| Only index persons | 0.11 | 0.13 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 50.59 | 50.50 | 51.24 |
| Only index persons | 50.44 | 50.39 | 50.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 761 | 621 | 140 |
| Unadjusted period prevalence (%) | 0.21 | 0.24 | 0.07 |
| Median age at first event (years) | 51.62 | 51.10 | 53.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint GRAVES_OPHT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GRAVES_OPHT | 0.959 [0.83, 1.1] | 0.558 |
| Birth year | 0.994 [0.99, 1.0] | 0.163 |
During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 3299 females with GRAVES_OPHT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GRAVES_OPHT | 0.932 [0.75, 1.16] | 0.532 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 762 males with GRAVES_OPHT died.
Mortality risk
Mortality risk for people of age
years, who have GRAVES_OPHT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | 0.178% |
| 5 | 0.592% | 1.02% |
| 10 | 1.423% | 2.475% |
| 15 | 2.785% | 4.756% |
| 20 | 4.852% | 8.199% |
Relationships between endpoints
↥Index endpoint: GRAVES_OPHT – Graves ophthalmopathy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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