lacrimal apparatus disease: A non-neoplastic or neoplastic disorder that affects the lacrimal apparatus. [ NCIT:C26809 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
41319 |
4. Check minimum number of eventsNone |
41319 |
5. Include endpoints |
42396 |
6. Filter based on genotype QC (FinnGen only) |
40848 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Disorders of eyelid, lacrimal system and orbit
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 331195 | 207011 | 122479 |
| Only index persons | 302064 | 192009 | 110055 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.98 | 5.93 | 3.42 |
| Only index persons | 6.02 | 7.06 | 4.20 |
| Median age at first event (years) | |||
| Whole population | 58.23 | 58.66 | 57.61 |
| Only index persons | 57.87 | 58.24 | 57.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 40848 | 26742 | 14106 |
| Unadjusted period prevalence (%) | 9.32 | 10.50 | 7.08 |
| Median age at first event (years) | 59.84 | 57.66 | 63.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_LIDLACRIMALORBIT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LIDLACRIMALORBIT | 0.979 [0.9, 1.06] | 0.61 |
| Birth year | 0.996 [0.99, 1.0] | 0.277 |
During the follow-up period (1.1.1998 — 31.12.2019), 24717 out of 165568 females with H7_LIDLACRIMALORBIT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LIDLACRIMALORBIT | 1.107 [1.01, 1.21] | 0.031 |
| Birth year | 0.986 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 18894 out of 98510 males with H7_LIDLACRIMALORBIT died.
Mortality risk
Mortality risk for people of age
years, who have H7_LIDLACRIMALORBIT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.115% | 0.184% |
| 5 | 0.56% | 1.363% |
| 10 | 1.368% | 3.053% |
| 15 | 2.6% | 5.756% |
| 20 | 4.725% | 9.664% |
Relationships between endpoints
↥Index endpoint: H7_LIDLACRIMALORBIT – Disorders of eyelid, lacrimal system and orbit
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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