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Other inflammation of eyelid

DOID EFO Endpoint Browser PheWeb

H7_EYELIDINFLAMMATION

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H01
  • Hospital discharge: ICD-9 — 373
  • Hospital discharge: ICD-8 — 361
  • Hospital discharge: excluded ICD-9 — 373[1-2]
  • Cause of death: ICD-10 — H01
  • Cause of death: ICD-9 — 373
  • Cause of death: ICD-8 — 361
  • Cause of death: excluded ICD-9 — 373[1-2]

2 out of 7 registries used, show all original rules.

4657

4. Check minimum number of events

None

4657

5. Include endpoints

None

4657

6. Filter based on genotype QC (FinnGen only)

4450

Control definitions (FinnGen only)

Control exclude H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H00-H06
Name in latin Alia inflammatio palpebrae/palpebrarum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 35649 20926 14563
Only index persons 32969 19642 13327
Unadjusted period prevalence (%)
Whole population 0.52 0.60 0.41
Only index persons 0.64 0.72 0.51
Median age at first event (years)
Whole population 54.12 55.30 52.57
Only index persons 55.38 56.20 54.16

-FinnGen-

Key figures

All Female Male
Number of individuals 4450 2848 1602
Unadjusted period prevalence (%) 1.01 1.12 0.80
Median age at first event (years) 60.39 57.76 65.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_EYELIDINFLAMMATION and mortality.

Females

Parameter HR [95% CI] p-value
H7_EYELIDINFLAMMATION 0.87 [0.77, 0.99] 0.035
Birth year 1.002 [0.99, 1.01] 0.704

During the follow-up period (1.1.1998 — 31.12.2019), 1561 out of 15950 females with H7_EYELIDINFLAMMATION died.

Males

Parameter HR [95% CI] p-value
H7_EYELIDINFLAMMATION 1.096 [0.95, 1.27] 0.209
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 1516 out of 11158 males with H7_EYELIDINFLAMMATION died.

Mortality risk

Mortality risk for people of age

years, who have H7_EYELIDINFLAMMATION.

N-year risk Females Males
1 0.102% 0.196%
5 0.65% 1.162%
10 1.533% 2.865%
15 3.177% 5.748%
20 5.832% 9.912%

Relationships between endpoints

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Index endpoint: H7_EYELIDINFLAMMATION – Other inflammation of eyelid

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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