No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
17924 |
4. Check minimum number of eventsNone |
17924 |
5. Include endpoints |
18329 |
6. Filter based on genotype QC (FinnGen only) |
17791 |
Control definitions (FinnGen only)
Control exclude
H7_LIDLACRIMALORBIT
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other disorders of eyelid
based on the number of shared cases.
Similar with more cases:
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 130802 | 82230 | 47984 |
| Only index persons | 118644 | 76174 | 42470 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.98 | 2.36 | 1.34 |
| Only index persons | 2.38 | 2.80 | 1.62 |
| Median age at first event (years) | |||
| Whole population | 66.66 | 65.77 | 68.10 |
| Only index persons | 65.92 | 65.05 | 67.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 17791 | 10969 | 6822 |
| Unadjusted period prevalence (%) | 3.97 | 4.31 | 3.43 |
| Median age at first event (years) | 64.91 | 62.33 | 69.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_EYELIDDIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EYELIDDIS | 0.972 [0.9, 1.05] | 0.489 |
| Birth year | 0.99 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 13775 out of 66434 females with H7_EYELIDDIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EYELIDDIS | 1.037 [0.95, 1.14] | 0.439 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 10952 out of 38830 males with H7_EYELIDDIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_EYELIDDIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.199% |
| 5 | 0.538% | 1.253% |
| 10 | 1.319% | 3.068% |
| 15 | 2.357% | 5.828% |
| 20 | 4.171% | 10.179% |
Relationships between endpoints
↥Index endpoint: H7_EYELIDDIS – Other disorders of eyelid
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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