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Ectropion of eyelid

DOID EFO Endpoint Browser PheWeb

H7_ECTROPION

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H02.1
  • Hospital discharge: ICD-9 — 3741
  • Hospital discharge: ICD-8 — 37811
  • Cause of death: ICD-10 — H02.1
  • Cause of death: ICD-9 — 3741
  • Cause of death: ICD-8 — 37811

2 out of 7 registries used, show all original rules.

1318

4. Check minimum number of events

None

1318

5. Include endpoints

None

1318

6. Filter based on genotype QC (FinnGen only)

1272

Control definitions (FinnGen only)

Control exclude H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H02
Name in latin Ectropium (palpebrae)

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12729 5446 7166
Only index persons 10216 4586 5630
Unadjusted period prevalence (%)
Whole population 0.18 0.16 0.20
Only index persons 0.19 0.17 0.21
Median age at first event (years)
Whole population 77.77 79.83 76.20
Only index persons 77.93 79.92 76.30

-FinnGen-

Key figures

All Female Male
Number of individuals 1272 410 862
Unadjusted period prevalence (%) 0.35 0.16 0.43
Median age at first event (years) 75.96 75.93 75.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_ECTROPION and mortality.

Females

Parameter HR [95% CI] p-value
H7_ECTROPION 1.089 [0.97, 1.22] 0.15
Birth year 0.994 [0.99, 1.0] 0.15

During the follow-up period (1.1.1998 — 31.12.2019), 2074 out of 4377 females with H7_ECTROPION died.

Males

Parameter HR [95% CI] p-value
H7_ECTROPION 1.213 [1.06, 1.38] 0.004
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 2725 out of 5467 males with H7_ECTROPION died.

Mortality risk

Mortality risk for people of age

years, who have H7_ECTROPION.

N-year risk Females Males
1 0.076% 0.239%
5 0.598% 1.342%
10 1.433% 3.469%
15 2.943% 6.614%
20 5.09% 11.054%

Relationships between endpoints

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Index endpoint: H7_ECTROPION – Ectropion of eyelid

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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