No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
10970 |
4. Check minimum number of eventsNone |
10970 |
5. Include endpointsNone |
10970 |
6. Filter based on genotype QC (FinnGen only) |
10684 |
Control definitions (FinnGen only)
Control exclude
H7_LIDLACRIMALORBIT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H02
Name in latin
Dermatochalasis
Similar endpoints
↥List of similar endpoints to
Blepharochalasis
based on the number of shared cases.
Similar with more cases:
- Other disorders of eyelid
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 66351 | 47232 | 18948 |
| Only index persons | 63111 | 45180 | 17931 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.11 | 1.35 | 0.53 |
| Only index persons | 1.38 | 1.66 | 0.68 |
| Median age at first event (years) | |||
| Whole population | 64.88 | 64.11 | 66.77 |
| Only index persons | 64.53 | 63.74 | 66.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10684 | 7332 | 3352 |
| Unadjusted period prevalence (%) | 2.50 | 2.88 | 1.68 |
| Median age at first event (years) | 63.85 | 62.23 | 67.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_BLEPHAROCHALASIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLEPHAROCHALASIS | 0.789 [0.73, 0.85] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.216 |
During the follow-up period (1.1.1998 — 31.12.2019), 5529 out of 37804 females with H7_BLEPHAROCHALASIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLEPHAROCHALASIS | 0.903 [0.82, 1.0] | 0.04 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 3131 out of 15678 males with H7_BLEPHAROCHALASIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_BLEPHAROCHALASIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | 0.159% |
| 5 | 0.439% | 1.127% |
| 10 | 1.108% | 2.791% |
| 15 | 2.133% | 5.154% |
| 20 | 3.839% | 8.469% |
Relationships between endpoints
↥Index endpoint: H7_BLEPHAROCHALASIS – Blepharochalasis
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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