≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Lagophthalmos

DOID EFO Endpoint Browser PheWeb

H7_LAGOPHTALMOS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H02.2
  • Hospital discharge: ICD-9 — 3742
  • Hospital discharge: ICD-8 — 37813
  • Cause of death: ICD-10 — H02.2
  • Cause of death: ICD-9 — 3742
  • Cause of death: ICD-8 — 37813

2 out of 7 registries used, show all original rules.

366

4. Check minimum number of events

None

366

5. Include endpoints

None

366

6. Filter based on genotype QC (FinnGen only)

350

Control definitions (FinnGen only)

Control exclude H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H02
Name in latin Lagophthalmus

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3022 1641 1356
Only index persons 2486 1397 1089
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.05 0.05 0.04
Median age at first event (years)
Whole population 65.73 66.16 65.28
Only index persons 65.12 65.30 64.89

-FinnGen-

Key figures

All Female Male
Number of individuals 350 190 160
Unadjusted period prevalence (%) 0.08 0.07 0.08
Median age at first event (years) 65.11 62.81 67.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

↥

Association

Association between endpoint H7_LAGOPHTALMOS and mortality.

Females

Parameter HR [95% CI] p-value
H7_LAGOPHTALMOS 1.358 [1.15, 1.61] < 0.001
Birth year 0.997 [0.99, 1.01] 0.529

During the follow-up period (1.1.1998 — 31.12.2019), 392 out of 1238 females with H7_LAGOPHTALMOS died.

Males

Parameter HR [95% CI] p-value
H7_LAGOPHTALMOS 1.744 [1.42, 2.14] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 375 out of 944 males with H7_LAGOPHTALMOS died.

Mortality risk

Mortality risk for people of age

years, who have H7_LAGOPHTALMOS.

N-year risk Females Males
1 0.119% 0.273%
5 0.782% 1.808%
10 2.201% 4.344%
15 4.166% 8.147%
20 6.923% 13.65%

Relationships between endpoints

↥

Index endpoint: H7_LAGOPHTALMOS – Lagophthalmos

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data