No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3588 |
4. Check minimum number of eventsNone |
3588 |
5. Include endpointsNone |
3588 |
6. Filter based on genotype QC (FinnGen only) |
3479 |
Control definitions (FinnGen only)
Control exclude
H7_LIDLACRIMALORBIT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H02
Name in latin
Ptosis palpebrae
Similar endpoints
↥List of similar endpoints to
Ptosis of eyelid
based on the number of shared cases.
Similar with more cases:
- Other disorders of eyelid
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22188 | 13177 | 8939 |
| Only index persons | 20874 | 12492 | 8382 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.33 | 0.38 | 0.25 |
| Only index persons | 0.40 | 0.46 | 0.32 |
| Median age at first event (years) | |||
| Whole population | 66.32 | 66.36 | 66.26 |
| Only index persons | 66.07 | 66.04 | 66.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3479 | 2028 | 1451 |
| Unadjusted period prevalence (%) | 0.77 | 0.80 | 0.73 |
| Median age at first event (years) | 65.15 | 63.78 | 67.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_PTOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PTOSIS | 0.9 [0.81, 1.0] | 0.044 |
| Birth year | 1.0 [0.99, 1.01] | 0.9 |
During the follow-up period (1.1.1998 — 31.12.2019), 1753 out of 10835 females with H7_PTOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PTOSIS | 0.938 [0.83, 1.06] | 0.314 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1344 out of 7364 males with H7_PTOSIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_PTOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.187% |
| 5 | 0.484% | 1.068% |
| 10 | 1.328% | 2.775% |
| 15 | 2.607% | 5.238% |
| 20 | 4.892% | 8.645% |
Relationships between endpoints
↥Index endpoint: H7_PTOSIS – Ptosis of eyelid
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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