hordeolum: Hordeolum is a sequelae of infectious and parasitic disease consisting of an infection of the sebaceous glands at the base of the eyelashes. Styes are generally caused by a Staphylococcus aureus bacterial infection.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1885 |
4. Check minimum number of eventsNone |
1885 |
5. Include endpointsNone |
1885 |
6. Filter based on genotype QC (FinnGen only) |
1794 |
Control definitions (FinnGen only)
Control exclude
H7_LIDLACRIMALORBIT
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Hordeolum and other deep inflammation of eyelid
based on the number of shared cases.
Similar with more cases:
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19445 | 10374 | 8926 |
| Only index persons | 17154 | 9350 | 7804 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.30 | 0.25 |
| Only index persons | 0.32 | 0.34 | 0.30 |
| Median age at first event (years) | |||
| Whole population | 38.04 | 39.24 | 36.67 |
| Only index persons | 41.15 | 42.26 | 39.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1794 | 1109 | 685 |
| Unadjusted period prevalence (%) | 0.40 | 0.44 | 0.34 |
| Median age at first event (years) | 51.85 | 50.28 | 54.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_HORDEOLUM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_HORDEOLUM | 1.014 [0.88, 1.18] | 0.851 |
| Birth year | 0.998 [0.99, 1.01] | 0.673 |
During the follow-up period (1.1.1998 — 31.12.2019), 525 out of 8213 females with H7_HORDEOLUM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_HORDEOLUM | 1.166 [1.01, 1.35] | 0.042 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 619 out of 7082 males with H7_HORDEOLUM died.
Mortality risk
Mortality risk for people of age
years, who have H7_HORDEOLUM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | 0.202% |
| 5 | 0.635% | 1.336% |
| 10 | 1.674% | 3.251% |
| 15 | 3.379% | 6.237% |
| 20 | 5.96% | 10.647% |
Relationships between endpoints
↥Index endpoint: H7_HORDEOLUM – Hordeolum and other deep inflammation of eyelid
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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