lacrimal apparatus disease: A non-neoplastic or neoplastic disorder that affects the lacrimal apparatus. [ NCIT:C26809 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
17136 |
4. Check minimum number of eventsNone |
17136 |
5. Include endpoints |
17593 |
6. Filter based on genotype QC (FinnGen only) |
16875 |
Control definitions (FinnGen only)
Control exclude
H7_LIDLACRIMALORBIT
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H00-H06
Name in latin
Morbositates apparati lacrimalis
Similar endpoints
↥List of similar endpoints to
Disorders of lacrimal system
based on the number of shared cases.
Similar with more cases:
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 127870 | 87438 | 39761 |
| Only index persons | 117779 | 81553 | 36226 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.06 | 2.50 | 1.11 |
| Only index persons | 2.50 | 3.00 | 1.38 |
| Median age at first event (years) | |||
| Whole population | 56.97 | 57.90 | 55.11 |
| Only index persons | 56.75 | 57.49 | 55.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 16875 | 12180 | 4695 |
| Unadjusted period prevalence (%) | 4.11 | 4.78 | 2.36 |
| Median age at first event (years) | 58.49 | 56.97 | 62.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_LACRIMALSYSTEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LACRIMALSYSTEM | 1.049 [0.96, 1.15] | 0.289 |
| Birth year | 0.997 [0.99, 1.01] | 0.484 |
During the follow-up period (1.1.1998 — 31.12.2019), 9340 out of 68110 females with H7_LACRIMALSYSTEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LACRIMALSYSTEM | 1.159 [1.05, 1.28] | 0.005 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5350 out of 31150 males with H7_LACRIMALSYSTEM died.
Mortality risk
Mortality risk for people of age
years, who have H7_LACRIMALSYSTEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.241% |
| 5 | 0.584% | 1.34% |
| 10 | 1.53% | 3.285% |
| 15 | 2.935% | 5.892% |
| 20 | 5.334% | 10.039% |
Relationships between endpoints
↥Index endpoint: H7_LACRIMALSYSTEM – Disorders of lacrimal system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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