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Stenosis and insufficiency of lacrimal passages

DOID EFO Endpoint Browser PheWeb

H7_STENOLACRI

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H04.5
  • Hospital discharge: ICD-9 — 3755
  • Hospital discharge: ICD-8 — 36802
  • Cause of death: ICD-10 — H04.5
  • Cause of death: ICD-9 — 3755
  • Cause of death: ICD-8 — 36802

2 out of 7 registries used, show all original rules.

3350

4. Check minimum number of events

None

3350

5. Include endpoints

None

3350

6. Filter based on genotype QC (FinnGen only)

3232

Control definitions (FinnGen only)

Control exclude H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H04
Name in latin Stenosis et/sive insufficientia viarum lacrimalium

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 32019 21562 10334
Only index persons 27395 18897 8498
Unadjusted period prevalence (%)
Whole population 0.51 0.62 0.29
Only index persons 0.58 0.69 0.32
Median age at first event (years)
Whole population 53.81 56.82 47.43
Only index persons 53.93 56.56 48.06

-FinnGen-

Key figures

All Female Male
Number of individuals 3232 2325 907
Unadjusted period prevalence (%) 0.78 0.91 0.46
Median age at first event (years) 58.61 57.21 62.21

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_STENOLACRI and mortality.

Females

Parameter HR [95% CI] p-value
H7_STENOLACRI 0.837 [0.76, 0.92] < 0.001
Birth year 0.996 [0.99, 1.0] 0.322

During the follow-up period (1.1.1998 — 31.12.2019), 2226 out of 15639 females with H7_STENOLACRI died.

Males

Parameter HR [95% CI] p-value
H7_STENOLACRI 0.921 [0.82, 1.03] 0.155
Birth year 0.99 [0.98, 1.0] 0.03

During the follow-up period (1.1.1998 — 31.12.2019), 1205 out of 7490 males with H7_STENOLACRI died.

Mortality risk

Mortality risk for people of age

years, who have H7_STENOLACRI.

N-year risk Females Males
1 0.082% 0.164%
5 0.508% 1.095%
10 1.342% 2.76%
15 2.472% 5.507%
20 4.285% 9.351%

Relationships between endpoints

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Index endpoint: H7_STENOLACRI – Stenosis and insufficiency of lacrimal passages

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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