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Inflammation of lacrimal passages (acute and unspecified)

DOID EFO Endpoint Browser PheWeb

H7_LACRIMINFLAMACU

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H04.3
  • Hospital discharge: ICD-9 — 3753
  • Hospital discharge: ICD-8 — 36803
  • Cause of death: ICD-10 — H04.3
  • Cause of death: ICD-9 — 3753
  • Cause of death: ICD-8 — 36803

2 out of 7 registries used, show all original rules.

563

4. Check minimum number of events

None

563

5. Include endpoints

None

563

6. Filter based on genotype QC (FinnGen only)

540

Control definitions (FinnGen only)

Control exclude H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H04
Name in latin Inflammatio viarum lacrimalium acuta sive non specificata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5708 4089 1592
Only index persons 4945 3555 1390
Unadjusted period prevalence (%)
Whole population 0.10 0.12 0.04
Only index persons 0.11 0.13 0.05
Median age at first event (years)
Whole population 58.12 62.11 48.00
Only index persons 56.05 59.83 46.38

-FinnGen-

Key figures

All Female Male
Number of individuals 540 400 140
Unadjusted period prevalence (%) 0.13 0.16 0.07
Median age at first event (years) 56.74 56.05 58.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint H7_LACRIMINFLAMACU and mortality.

Females

Parameter HR [95% CI] p-value
H7_LACRIMINFLAMACU 1.139 [1.0, 1.3] 0.053
Birth year 0.995 [0.99, 1.0] 0.211

During the follow-up period (1.1.1998 — 31.12.2019), 749 out of 3226 females with H7_LACRIMINFLAMACU died.

Males

Parameter HR [95% CI] p-value
H7_LACRIMINFLAMACU 1.276 [1.02, 1.59] 0.031
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1257 males with H7_LACRIMINFLAMACU died.

Mortality risk

Mortality risk for people of age

years, who have H7_LACRIMINFLAMACU.

N-year risk Females Males
1 0.103% 0.272%
5 0.591% 1.552%
10 1.593% 3.938%
15 2.97% 7.327%
20 5.483% 12.006%

Relationships between endpoints

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Index endpoint: H7_LACRIMINFLAMACU – Inflammation of lacrimal passages (acute and unspecified)

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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