No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
670 |
4. Check minimum number of eventsNone |
670 |
5. Include endpointsNone |
670 |
6. Filter based on genotype QC (FinnGen only) |
646 |
Control definitions (FinnGen only)
Control exclude
H7_LIDLACRIMALORBIT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H04
Name in latin
Epiphora
Similar endpoints
↥List of similar endpoints to
Epiphora
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5034 | 3324 | 1700 |
| Only index persons | 4691 | 3161 | 1530 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.05 |
| Only index persons | 0.10 | 0.12 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 58.49 | 57.92 | 59.66 |
| Only index persons | 58.69 | 58.09 | 59.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 646 | 463 | 183 |
| Unadjusted period prevalence (%) | 0.16 | 0.18 | 0.09 |
| Median age at first event (years) | 60.87 | 59.25 | 64.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_EPIPHORA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EPIPHORA | 0.846 [0.73, 0.98] | 0.023 |
| Birth year | 0.995 [0.99, 1.0] | 0.288 |
During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 2954 females with H7_EPIPHORA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EPIPHORA | 0.996 [0.84, 1.18] | 0.961 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 302 out of 1479 males with H7_EPIPHORA died.
Mortality risk
Mortality risk for people of age
years, who have H7_EPIPHORA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.104% | 0.193% |
| 5 | 0.536% | 1.29% |
| 10 | 1.339% | 3.071% |
| 15 | 2.565% | 5.718% |
| 20 | 4.456% | 9.408% |
Relationships between endpoints
↥Index endpoint: H7_EPIPHORA – Epiphora
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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