No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1401 |
4. Check minimum number of eventsNone |
1401 |
5. Include endpoints |
1495 |
6. Filter based on genotype QC (FinnGen only) |
1447 |
Control definitions (FinnGen only)
Control exclude
H7_LIDLACRIMALORBIT
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorders of orbit
based on the number of shared cases.
Similar with more cases:
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11521 | 7147 | 4305 |
| Only index persons | 10492 | 6687 | 3805 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.20 | 0.12 |
| Only index persons | 0.21 | 0.25 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 48.52 | 51.10 | 44.14 |
| Only index persons | 48.17 | 50.74 | 43.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1447 | 1017 | 430 |
| Unadjusted period prevalence (%) | 0.34 | 0.40 | 0.22 |
| Median age at first event (years) | 52.02 | 51.71 | 52.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_ORBIT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBIT | 1.329 [1.18, 1.49] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.125 |
During the follow-up period (1.1.1998 — 31.12.2019), 737 out of 5877 females with H7_ORBIT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBIT | 1.431 [1.24, 1.65] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 575 out of 3310 males with H7_ORBIT died.
Mortality risk
Mortality risk for people of age
years, who have H7_ORBIT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.149% | 0.331% |
| 5 | 0.859% | 1.848% |
| 10 | 1.888% | 4.304% |
| 15 | 3.475% | 8.147% |
| 20 | 6.072% | 13.883% |
Relationships between endpoints
↥Index endpoint: H7_ORBIT – Disorders of orbit
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data