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Acute inflammation of orbit

DOID EFO Endpoint Browser PheWeb

H7_ORBITINFLAMACU

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H05.0
  • Hospital discharge: ICD-9 — 3760
  • Hospital discharge: ICD-8 — 3690[0-2]
  • Cause of death: ICD-10 — H05.0
  • Cause of death: ICD-9 — 3760
  • Cause of death: ICD-8 — 3690[0-2]

2 out of 7 registries used, show all original rules.

216

4. Check minimum number of events

None

216

5. Include endpoints

None

216

6. Filter based on genotype QC (FinnGen only)

213

Control definitions (FinnGen only)

Control exclude H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H05
Name in latin Inflammatio orbitae acuta

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2945 1284 1650
Only index persons 2527 1123 1404
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.05
Only index persons 0.05 0.04 0.05
Median age at first event (years)
Whole population 24.56 30.24 19.99
Only index persons 23.68 29.27 19.21

-FinnGen-

Key figures

All Female Male
Number of individuals 213 113 100
Unadjusted period prevalence (%) 0.05 0.04 0.05
Median age at first event (years) 42.84 39.30 46.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint H7_ORBITINFLAMACU and mortality.

Females

Parameter HR [95% CI] p-value
H7_ORBITINFLAMACU 1.673 [1.29, 2.17] < 0.001
Birth year 0.995 [0.99, 1.0] 0.21

During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 905 females with H7_ORBITINFLAMACU died.

Males

Parameter HR [95% CI] p-value
H7_ORBITINFLAMACU 1.943 [1.47, 2.57] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 1125 males with H7_ORBITINFLAMACU died.

Mortality risk

Mortality risk for people of age

years, who have H7_ORBITINFLAMACU.

N-year risk Females Males
1 0.162% 0.408%
5 0.981% 2.215%
10 2.452% 5.405%
15 4.582% 9.94%
20 7.866% 16.688%

Relationships between endpoints

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Index endpoint: H7_ORBITINFLAMACU – Acute inflammation of orbit

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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