No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
144 |
4. Check minimum number of eventsNone |
144 |
5. Include endpointsNone |
144 |
6. Filter based on genotype QC (FinnGen only) |
142 |
Control definitions (FinnGen only)
Control exclude
H7_LIDLACRIMALORBIT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified disorders of orbit
based on the number of shared cases.
Similar with more cases:
- Disorders of orbit
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1041 | 548 | 489 |
| Only index persons | 942 | 504 | 438 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.46 | 57.28 | 55.63 |
| Only index persons | 55.79 | 56.02 | 55.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 142 | 82 | 60 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 61.55 | 59.66 | 64.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_ORBITNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBITNAS | 1.807 [1.27, 2.57] | 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.157 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 411 females with H7_ORBITNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ORBITNAS | 1.939 [1.29, 2.91] | 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.021 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 371 males with H7_ORBITNAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_ORBITNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.144% | 0.383% |
| 5 | 0.889% | 2.239% |
| 10 | 2.464% | 5.928% |
| 15 | 4.762% | 11.4% |
| 20 | 8.392% | 19.205% |
Relationships between endpoints
↥Index endpoint: H7_ORBITNAS – Other and unspecified disorders of orbit
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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