Chronic inflammatory disorders of orbit

H7_ORBITINFLAMCHRON

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H05.1
  • Hospital discharge: ICD-9 3761
  • Cause of death: ICD-10 H05.1
  • Cause of death: ICD-9 3761

2 out of 7 registries used, show all original rules.

85

4. Check minimum number of events

None

85

5. Include endpoints

None

85

6. Filter based on genotype QC (FinnGen only)

83

Control definitions (FinnGen only)

Control exclude H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H05
Name in latin Inflammatio orbitae chronica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 733 362 363
Only index persons 668 330 338
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 50.37 54.07 46.47
Only index persons 49.07 52.64 45.59

-FinnGen-

Key figures

All Female Male
Number of individuals 83 45 38
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 49.98 47.68 52.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H7_ORBITINFLAMCHRON and mortality.

Females

Parameter HR [95% CI] p-value
H7_ORBITINFLAMCHRON 1.538 [1.15, 2.05] 0.004
Birth year 0.999 [0.99, 1.01] 0.863

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 272 females with H7_ORBITINFLAMCHRON died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_ORBITINFLAMCHRON.

N-year risk Females Males
1 0.183% No data
5 1.03% No data
10 2.504% No data
15 4.872% No data
20 8.812% No data

Relationships between endpoints

Index endpoint: H7_ORBITINFLAMCHRON – Chronic inflammatory disorders of orbit

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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