No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
675 |
4. Check minimum number of eventsNone |
675 |
5. Include endpointsNone |
675 |
6. Filter based on genotype QC (FinnGen only) |
646 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF7
Similar endpoints
↥List of similar endpoints to
Graves ophthalmopathy, strict
based on the number of shared cases.
Similar with more cases:
- Graves ophthalmopathy
- Disorders of lacrimal system and orbit in diseases classified elsewhere
- Disorders of orbit
- Thyrotoxicosis, other and/or unspecified
- Thyrotoxicosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3679 | 2975 | 690 |
| Only index persons | 3569 | 2906 | 663 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.09 | 0.02 |
| Only index persons | 0.09 | 0.11 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 51.38 | 51.28 | 51.88 |
| Only index persons | 51.22 | 51.20 | 51.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 646 | 524 | 122 |
| Unadjusted period prevalence (%) | 0.18 | 0.21 | 0.06 |
| Median age at first event (years) | 52.68 | 52.38 | 53.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_GRAVES_OPHT_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_OPHT_STRICT | 1.019 [0.88, 1.18] | 0.809 |
| Birth year | 0.997 [0.99, 1.01] | 0.467 |
During the follow-up period (1.1.1998 — 31.12.2019), 232 out of 2730 females with E4_GRAVES_OPHT_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_OPHT_STRICT | 0.955 [0.75, 1.22] | 0.706 |
| Birth year | 0.988 [0.98, 1.0] | 0.021 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 636 males with E4_GRAVES_OPHT_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have E4_GRAVES_OPHT_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.132% | 0.18% |
| 5 | 0.714% | 1.192% |
| 10 | 1.575% | 3.121% |
| 15 | 2.786% | 5.749% |
| 20 | 5.019% | 9.82% |
Relationships between endpoints
↥Index endpoint: E4_GRAVES_OPHT_STRICT – Graves ophthalmopathy, strict
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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