This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Atrophy of thyroid (acquired)
E4_ATROTHY
hypothyroidism: Abnormally low levels of thyroid hormone.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
45 |
4. Check minimum number of eventsNone |
45 |
5. Include endpointsNone |
45 |
6. Filter based on genotype QC (FinnGen only) |
43 |
Control definitions (FinnGen only)
Control exclude
E4_THYROID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E03
Name in latin
Atrophia glandulae thyreoideae [acquisita]
Similar endpoints
↥List of similar endpoints to
Atrophy of thyroid (acquired)
based on the number of shared cases.
Similar with more cases:
- Hypothyroidism (congenital or acquired)
- Hypothyreosis and Thyroxine purchase for inclusion criteria
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 551 | 413 | 132 |
| Only index persons | 364 | 274 | 90 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 64.16 | 64.40 | 63.12 |
| Only index persons | 55.98 | 56.10 | 55.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 43 | 37 | 6 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | 53.81 | 51.83 | 66.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint E4_ATROTHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ATROTHY | 1.365 [0.88, 2.11] | 0.16 |
| Birth year | 1.0 [0.99, 1.01] | 0.991 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 182 females with E4_ATROTHY died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_ATROTHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | No data |
| 5 | 0.83% | No data |
| 10 | 1.972% | No data |
| 15 | 4.112% | No data |
| 20 | 7.823% | No data |
Relationships between endpoints
↥Index endpoint: E4_ATROTHY – Atrophy of thyroid (acquired)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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