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Nontoxic multinodular goitre

DOID EFO Endpoint Browser PheWeb

E4_GOITREMULTINOD

nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E04.2
  • Hospital discharge: ICD-9 — 2411
  • Hospital discharge: ICD-8 — 241
  • Cause of death: ICD-10 — E04.2
  • Cause of death: ICD-9 — 2411
  • Cause of death: ICD-8 — 241

2 out of 7 registries used, show all original rules.

7696

4. Check minimum number of events

None

7696

5. Include endpoints

None

7696

6. Filter based on genotype QC (FinnGen only)

7423

Control definitions (FinnGen only)

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E04
Name in latin Struma atoxica multinodularis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 61722 52630 8754
Only index persons 53558 46255 7303
Unadjusted period prevalence (%)
Whole population 1.32 1.51 0.24
Only index persons 1.51 1.70 0.28
Median age at first event (years)
Whole population 53.21 52.57 57.09
Only index persons 52.22 51.51 56.67

-FinnGen-

Key figures

All Female Male
Number of individuals 7423 6249 1174
Unadjusted period prevalence (%) 2.16 2.45 0.59
Median age at first event (years) 52.42 51.00 59.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint E4_GOITREMULTINOD and mortality.

Females

Parameter HR [95% CI] p-value
E4_GOITREMULTINOD 0.943 [0.87, 1.02] 0.167
Birth year 0.992 [0.98, 1.0] 0.055

During the follow-up period (1.1.1998 — 31.12.2019), 3745 out of 27526 females with E4_GOITREMULTINOD died.

Males

Parameter HR [95% CI] p-value
E4_GOITREMULTINOD 0.966 [0.87, 1.07] 0.519
Birth year 0.987 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 982 out of 5001 males with E4_GOITREMULTINOD died.

Mortality risk

Mortality risk for people of age

years, who have E4_GOITREMULTINOD.

N-year risk Females Males
1 0.095% 0.187%
5 0.505% 1.23%
10 1.242% 2.97%
15 2.22% 5.37%
20 4.119% 8.844%

Relationships between endpoints

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Index endpoint: E4_GOITREMULTINOD – Nontoxic multinodular goitre

GWS hits: 44

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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