No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
11873 |
6. Filter based on genotype QC (FinnGen only) |
11446 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF7
Similar endpoints
↥List of similar endpoints to
Nontoxic goitre/thyroid nodule
based on the number of shared cases.
Similar with more cases:
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 94629 | 79516 | 14590 |
| Only index persons | 83422 | 70990 | 12432 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.98 | 2.28 | 0.41 |
| Only index persons | 2.29 | 2.61 | 0.47 |
| Median age at first event (years) | |||
| Whole population | 53.07 | 52.37 | 56.86 |
| Only index persons | 52.03 | 51.30 | 56.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 11446 | 9520 | 1926 |
| Unadjusted period prevalence (%) | 3.27 | 3.74 | 0.97 |
| Median age at first event (years) | 51.77 | 50.28 | 59.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_NONTOXIC_THYROID and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_NONTOXIC_THYROID | 0.99 [0.91, 1.07] | 0.797 |
| Birth year | 0.99 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 5962 out of 44264 females with E4_NONTOXIC_THYROID died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_NONTOXIC_THYROID | 0.999 [0.91, 1.1] | 0.977 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1762 out of 8829 males with E4_NONTOXIC_THYROID died.
Mortality risk
Mortality risk for people of age
years, who have E4_NONTOXIC_THYROID.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.085% | 0.134% |
| 5 | 0.517% | 0.972% |
| 10 | 1.226% | 2.72% |
| 15 | 2.424% | 5.03% |
| 20 | 4.227% | 8.358% |
Relationships between endpoints
↥Index endpoint: E4_NONTOXIC_THYROID – Nontoxic goitre/thyroid nodule
GWS hits: 56
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data