No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1045 |
4. Check minimum number of eventsNone |
1045 |
5. Include endpointsNone |
1045 |
6. Filter based on genotype QC (FinnGen only) |
1007 |
Control definitions (FinnGen only)
Control exclude
E4_THYROID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E04
Name in latin
Struma atoxica diffusa
Similar endpoints
↥List of similar endpoints to
Nontoxic diffuse goitre
based on the number of shared cases.
Similar with more cases:
- Nontoxic goitre/thyroid nodule
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8966 | 7514 | 1404 |
| Only index persons | 7805 | 6684 | 1121 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.22 | 0.04 |
| Only index persons | 0.22 | 0.25 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 54.97 | 54.35 | 58.33 |
| Only index persons | 53.79 | 53.13 | 57.68 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1007 | 853 | 154 |
| Unadjusted period prevalence (%) | 0.30 | 0.34 | 0.08 |
| Median age at first event (years) | 52.23 | 51.12 | 58.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_GOITREDIFF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITREDIFF | 1.08 [0.97, 1.2] | 0.166 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 753 out of 4980 females with E4_GOITREDIFF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITREDIFF | 1.199 [1.0, 1.44] | 0.05 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 886 males with E4_GOITREDIFF died.
Mortality risk
Mortality risk for people of age
years, who have E4_GOITREDIFF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.187% |
| 5 | 0.582% | 1.244% |
| 10 | 1.489% | 3.239% |
| 15 | 2.926% | 5.961% |
| 20 | 5.264% | 10.079% |
Relationships between endpoints
↥Index endpoint: E4_GOITREDIFF – Nontoxic diffuse goitre
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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