nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2583 |
4. Check minimum number of eventsNone |
2583 |
5. Include endpointsNone |
2583 |
6. Filter based on genotype QC (FinnGen only) |
2476 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to
Nontoxic single thyroid nodule
based on the number of shared cases.
Similar with more cases:
- Nontoxic goitre/thyroid nodule
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 17821 | 14391 | 3351 |
Only index persons | 16839 | 13735 | 3104 |
Unadjusted period prevalence (%) | |||
Whole population | 0.35 | 0.41 | 0.09 |
Only index persons | 0.43 | 0.50 | 0.12 |
Median age at first event (years) | |||
Whole population | 51.50 | 50.54 | 55.53 |
Only index persons | 50.93 | 50.05 | 54.82 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 2476 | 2000 | 476 |
Unadjusted period prevalence (%) | 0.68 | 0.79 | 0.24 |
Median age at first event (years) | 51.16 | 49.27 | 59.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_GOITRENOD and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
E4_GOITRENOD | 0.933 [0.84, 1.03] | 0.168 |
Birth year | 0.994 [0.99, 1.0] | 0.161 |
During the follow-up period (1.1.1998 — 31.12.2019), 978 out of 10026 females with E4_GOITRENOD died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
E4_GOITRENOD | 0.863 [0.76, 0.98] | 0.019 |
Birth year | 0.993 [0.98, 1.0] | 0.145 |
During the follow-up period (1.1.1998 — 31.12.2019), 395 out of 2426 males with E4_GOITRENOD died.
Mortality risk
Mortality risk for people of age
years, who have E4_GOITRENOD.N-year risk | Females | Males |
---|---|---|
1 | 0.064% | 0.205% |
5 | 0.56% | 1.157% |
10 | 1.27% | 3.068% |
15 | 2.514% | 5.741% |
20 | 4.303% | 10.132% |
Relationships between endpoints
↥Index endpoint: E4_GOITRENOD – Nontoxic single thyroid nodule
GWS hits: 2