Nontoxic single thyroid nodule

E4_GOITRENOD

nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E04.1
  • Hospital discharge: ICD-9 2410|2462
  • Cause of death: ICD-10 E04.1
  • Cause of death: ICD-9 2410|2462

2 out of 7 registries used, show all original rules.

2583

4. Check minimum number of events

None

2583

5. Include endpoints

None

2583

6. Filter based on genotype QC (FinnGen only)

2476

Control definitions (FinnGen only)

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E04
Name in latin Struma atoxica uninodularis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17821 14391 3351
Only index persons 16839 13735 3104
Unadjusted period prevalence (%)
Whole population 0.35 0.41 0.09
Only index persons 0.43 0.50 0.12
Median age at first event (years)
Whole population 51.50 50.54 55.53
Only index persons 50.93 50.05 54.82

-FinnGen-

Key figures

All Female Male
Number of individuals 2476 2000 476
Unadjusted period prevalence (%) 0.68 0.79 0.24
Median age at first event (years) 51.16 49.27 59.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint E4_GOITRENOD and mortality.

Females

Parameter HR [95% CI] p-value
E4_GOITRENOD 0.933 [0.84, 1.03] 0.168
Birth year 0.994 [0.99, 1.0] 0.161

During the follow-up period (1.1.1998 — 31.12.2019), 978 out of 10026 females with E4_GOITRENOD died.

Males

Parameter HR [95% CI] p-value
E4_GOITRENOD 0.863 [0.76, 0.98] 0.019
Birth year 0.993 [0.98, 1.0] 0.145

During the follow-up period (1.1.1998 — 31.12.2019), 395 out of 2426 males with E4_GOITRENOD died.

Mortality risk

Mortality risk for people of age

years, who have E4_GOITRENOD.

N-year risk Females Males
1 0.064% 0.205%
5 0.56% 1.157%
10 1.27% 3.068%
15 2.514% 5.741%
20 4.303% 10.132%

Relationships between endpoints

Index endpoint: E4_GOITRENOD – Nontoxic single thyroid nodule

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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