goiter: Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2910 |
4. Check minimum number of eventsNone |
2910 |
5. Include endpointsNone |
2910 |
6. Filter based on genotype QC (FinnGen only) |
2804 |
Control definitions (FinnGen only)
Control exclude
E4_THYROID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and/or unspecified nontoxic goitre
based on the number of shared cases.
Similar with more cases:
- Nontoxic goitre/thyroid nodule
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22270 | 18757 | 3408 |
| Only index persons | 20487 | 17456 | 3031 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.47 | 0.54 | 0.10 |
| Only index persons | 0.56 | 0.64 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 57.28 | 56.61 | 61.03 |
| Only index persons | 56.26 | 55.63 | 59.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2804 | 2353 | 451 |
| Unadjusted period prevalence (%) | 0.81 | 0.92 | 0.23 |
| Median age at first event (years) | 54.22 | 52.82 | 61.54 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_GOITRENAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITRENAS | 1.061 [0.97, 1.17] | 0.221 |
| Birth year | 0.996 [0.99, 1.0] | 0.364 |
During the follow-up period (1.1.1998 — 31.12.2019), 2088 out of 13454 females with E4_GOITRENAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITRENAS | 1.154 [1.02, 1.31] | 0.028 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 606 out of 2491 males with E4_GOITRENAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_GOITRENAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.195% |
| 5 | 0.636% | 1.32% |
| 10 | 1.595% | 3.405% |
| 15 | 3.024% | 6.447% |
| 20 | 5.332% | 10.87% |
Relationships between endpoints
↥Index endpoint: E4_GOITRENAS – Other and/or unspecified nontoxic goitre
GWS hits: 16
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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