thyroid disease: A disease involving the thyroid gland.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
392 |
4. Check minimum number of eventsNone |
392 |
5. Include endpointsNone |
392 |
6. Filter based on genotype QC (FinnGen only) |
377 |
Control definitions (FinnGen only)
Control exclude
E4_THYROID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorder of thyroid, unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of thyroid
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3547 | 2760 | 749 |
| Only index persons | 2885 | 2275 | 610 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.02 |
| Only index persons | 0.07 | 0.08 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 47.04 | 46.23 | 49.67 |
| Only index persons | 43.39 | 42.46 | 46.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 377 | 307 | 70 |
| Unadjusted period prevalence (%) | 0.10 | 0.12 | 0.04 |
| Median age at first event (years) | 42.39 | 40.40 | 51.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDNASOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDNASOTH | 1.444 [1.16, 1.8] | 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.115 |
During the follow-up period (1.1.1998 — 31.12.2019), 162 out of 1145 females with E4_THYROIDNASOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDNASOTH | 0.919 [0.68, 1.25] | 0.585 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 391 males with E4_THYROIDNASOTH died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYROIDNASOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.15% | 0.156% |
| 5 | 0.893% | 1.064% |
| 10 | 2.105% | 2.826% |
| 15 | 3.935% | 5.346% |
| 20 | 6.989% | 8.95% |
Relationships between endpoints
↥Index endpoint: E4_THYROIDNASOTH – Disorder of thyroid, unspecified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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