hypothyroidism: Abnormally low levels of thyroid hormone.
Hypothyroidism due to medicaments and other exogenous substances
DOID EFO Endpoint Browser PheWeb
E4_HYTHYSUBS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
332 |
4. Check minimum number of eventsNone |
332 |
5. Include endpointsNone |
332 |
6. Filter based on genotype QC (FinnGen only) |
322 |
Control definitions (FinnGen only)
Control exclude
E4_THYROID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E03
Name in latin
Hypothyreosis ex medicamentis sive aliis substantiis externis
Similar endpoints
↥List of similar endpoints to
Hypothyroidism due to medicaments and other exogenous substances
based on the number of shared cases.
Similar with more cases:
- Hypothyroidism (congenital or acquired)
- Hypothyreosis and Thyroxine purchase for inclusion criteria
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2311 | 1701 | 600 |
| Only index persons | 2080 | 1546 | 534 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 61.87 | 61.63 | 62.70 |
| Only index persons | 60.73 | 60.33 | 61.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 322 | 236 | 86 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.04 |
| Median age at first event (years) | 57.20 | 55.17 | 62.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYTHYSUBS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYTHYSUBS | 1.474 [1.22, 1.77] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 266 out of 1295 females with E4_HYTHYSUBS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYTHYSUBS | 1.706 [1.2, 2.43] | 0.003 |
| Birth year | 0.991 [0.98, 1.0] | 0.059 |
During the follow-up period (1.1.1998 — 31.12.2019), 125 out of 448 males with E4_HYTHYSUBS died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYTHYSUBS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.126% | 0.325% |
| 5 | 0.678% | 1.992% |
| 10 | 1.908% | 5.386% |
| 15 | 3.619% | 10.489% |
| 20 | 6.044% | 17.534% |
Relationships between endpoints
↥Index endpoint: E4_HYTHYSUBS – Hypothyroidism due to medicaments and other exogenous substances
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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