gastric mucosal hypertrophy: MC)nC)trier disease (MD) is a rare premalignant hyperproliferative gastropathy characterized by massive overgrowth of foveolar cells in the gastric lining, resulting in large gastric folds, and manifesting with epigastric pain, nausea, vomiting, peripheral edema and, less commonly, anorexia and weight loss.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
67420 |
4. Check minimum number of eventsNone |
67420 |
5. Include endpoints |
71540 |
6. Filter based on genotype QC (FinnGen only) |
68651 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Diseases of oesophagus, stomach and duodenum
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 623888 | 321728 | 296006 |
| Only index persons | 515264 | 276763 | 238501 |
| Unadjusted period prevalence (%) | |||
| Whole population | 8.74 | 9.22 | 8.27 |
| Only index persons | 9.68 | 10.17 | 9.10 |
| Median age at first event (years) | |||
| Whole population | 58.01 | 59.54 | 56.27 |
| Only index persons | 56.26 | 57.62 | 54.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 68651 | 37497 | 31154 |
| Unadjusted period prevalence (%) | 15.14 | 14.73 | 15.65 |
| Median age at first event (years) | 57.09 | 55.07 | 59.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_OESSTODUO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OESSTODUO | 1.359 [1.26, 1.46] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.152 |
During the follow-up period (1.1.1998 — 31.12.2019), 55226 out of 243683 females with K11_OESSTODUO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OESSTODUO | 1.687 [1.56, 1.82] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 59241 out of 206058 males with K11_OESSTODUO died.
Mortality risk
Mortality risk for people of age
years, who have K11_OESSTODUO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.279% |
| 5 | 0.673% | 1.655% |
| 10 | 1.7% | 3.874% |
| 15 | 3.286% | 7.238% |
| 20 | 5.861% | 12.319% |
Relationships between endpoints
↥Index endpoint: K11_OESSTODUO – Diseases of oesophagus, stomach and duodenum
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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