No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2511 |
4. Check minimum number of eventsNone |
2511 |
5. Include endpointsNone |
2511 |
6. Filter based on genotype QC (FinnGen only) |
2420 |
Control definitions (FinnGen only)
Control exclude
K11_OESSTODUO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K22
Name in latin
Ulcus oesophagi
Similar endpoints
↥List of similar endpoints to
Ulcer of oesophagus
based on the number of shared cases.
Similar with more cases:
- Diseases of oesophagus, stomach and duodenum
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 21862 | 8022 | 13653 |
| Only index persons | 18409 | 6921 | 11488 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.32 | 0.23 | 0.38 |
| Only index persons | 0.37 | 0.25 | 0.44 |
| Median age at first event (years) | |||
| Whole population | 63.50 | 66.61 | 61.61 |
| Only index persons | 62.53 | 65.07 | 61.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2420 | 850 | 1570 |
| Unadjusted period prevalence (%) | 0.63 | 0.33 | 0.79 |
| Median age at first event (years) | 62.05 | 60.33 | 62.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_OESULC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OESULC | 1.598 [1.46, 1.74] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.318 |
During the follow-up period (1.1.1998 — 31.12.2019), 2593 out of 7064 females with K11_OESULC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OESULC | 1.748 [1.61, 1.9] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 4746 out of 11822 males with K11_OESULC died.
Mortality risk
Mortality risk for people of age
years, who have K11_OESULC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.157% | 0.33% |
| 5 | 0.909% | 2.066% |
| 10 | 2.222% | 5.323% |
| 15 | 4.496% | 9.727% |
| 20 | 8.291% | 16.153% |
Relationships between endpoints
↥Index endpoint: K11_OESULC – Ulcer of oesophagus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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