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Other diseases of oesophagus

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K11_OTHDISOES

esophageal disease: A non-neoplastic or neoplastic disorder that affects the esophagus. Representative examples of non-neoplastic disorders include esophagitis and esophageal ulcer. Representative examples of neoplastic disorders include carcinomas, lymphomas, and melanomas.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K22.4, K22.5, K22.6, K22.7, K22.8, K22.9
  • Hospital discharge: ICD-9 — 530[5-9]
  • Hospital discharge: ICD-8 — 5302|5309
  • Hospital discharge: excluded ICD-10 — K22.7
  • Cause of death: ICD-10 — K22.4, K22.5, K22.6, K22.7, K22.8, K22.9
  • Cause of death: ICD-9 — 530[5-9]
  • Cause of death: ICD-8 — 5302|5309

2 out of 7 registries used, show all original rules.

3619

4. Check minimum number of events

None

3619

5. Include endpoints

None

3619

6. Filter based on genotype QC (FinnGen only)

3492

Control definitions (FinnGen only)

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 36883 15648 20710
Only index persons 26347 11658 14689
Unadjusted period prevalence (%)
Whole population 0.52 0.45 0.58
Only index persons 0.50 0.43 0.56
Median age at first event (years)
Whole population 58.42 61.45 56.04
Only index persons 55.31 57.65 53.45

-FinnGen-

Key figures

All Female Male
Number of individuals 3492 1561 1931
Unadjusted period prevalence (%) 0.81 0.61 0.97
Median age at first event (years) 56.07 54.86 57.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_OTHDISOES and mortality.

Females

Parameter HR [95% CI] p-value
K11_OTHDISOES 1.631 [1.47, 1.81] < 0.001
Birth year 0.995 [0.99, 1.0] 0.189

During the follow-up period (1.1.1998 — 31.12.2019), 2146 out of 7088 females with K11_OTHDISOES died.

Males

Parameter HR [95% CI] p-value
K11_OTHDISOES 1.977 [1.78, 2.19] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 3602 out of 9535 males with K11_OTHDISOES died.

Mortality risk

Mortality risk for people of age

years, who have K11_OTHDISOES.

N-year risk Females Males
1 0.118% 0.288%
5 0.876% 2.143%
10 2.228% 5.142%
15 4.277% 8.977%
20 7.988% 14.684%

Relationships between endpoints

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Index endpoint: K11_OTHDISOES – Other diseases of oesophagus

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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