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Other gastritis (incl. Duodenitis)

DOID EFO Endpoint Browser PheWeb

K11_OTHGASTR

gastric mucosal hypertrophy: MC)nC)trier disease (MD) is a rare premalignant hyperproliferative gastropathy characterized by massive overgrowth of foveolar cells in the gastric lining, resulting in large gastric folds, and manifesting with epigastric pain, nausea, vomiting, peripheral edema and, less commonly, anorexia and weight loss.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K29.6, K29.7, K29.8, K29.9
  • Hospital discharge: ICD-9 — 5352|535[5-6]
  • Hospital discharge: ICD-8 — 5350[4-9]
  • Cause of death: ICD-10 — K29.6, K29.7, K29.8, K29.9
  • Cause of death: ICD-9 — 5352|535[5-6]
  • Cause of death: ICD-8 — 5350[4-9]

2 out of 7 registries used, show all original rules.

9407

4. Check minimum number of events

None

9407

5. Include endpoints

None

9407

6. Filter based on genotype QC (FinnGen only)

8993

Control definitions (FinnGen only)

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 84729 42865 41015
Only index persons 70311 36865 33446
Unadjusted period prevalence (%)
Whole population 1.18 1.23 1.15
Only index persons 1.32 1.36 1.28
Median age at first event (years)
Whole population 59.54 61.51 57.52
Only index persons 58.04 59.45 56.49

-FinnGen-

Key figures

All Female Male
Number of individuals 8993 4562 4431
Unadjusted period prevalence (%) 2.01 1.79 2.23
Median age at first event (years) 58.68 57.13 60.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_OTHGASTR and mortality.

Females

Parameter HR [95% CI] p-value
K11_OTHGASTR 1.377 [1.28, 1.48] < 0.001
Birth year 0.997 [0.99, 1.01] 0.501

During the follow-up period (1.1.1998 — 31.12.2019), 8632 out of 32208 females with K11_OTHGASTR died.

Males

Parameter HR [95% CI] p-value
K11_OTHGASTR 1.712 [1.57, 1.87] < 0.001
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 8926 out of 27343 males with K11_OTHGASTR died.

Mortality risk

Mortality risk for people of age

years, who have K11_OTHGASTR.

N-year risk Females Males
1 0.127% 0.321%
5 0.771% 1.997%
10 1.999% 4.607%
15 3.805% 8.509%
20 6.889% 14.092%

Relationships between endpoints

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Index endpoint: K11_OTHGASTR – Other gastritis (incl. Duodenitis)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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