dyspepsia: An uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach pain, bloating, heartburn, nausea, and vomiting. Causes include gastritis, gastric ulcer, gastroesophageal reflux disease, pancreatic disease, and gallbladder disease.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
11337 |
4. Check minimum number of eventsNone |
11337 |
5. Include endpointsNone |
11337 |
6. Filter based on genotype QC (FinnGen only) |
10851 |
Control definitions (FinnGen only)
Control exclude
K11_OESSTODUO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K20-K31
Name in latin
Dyspepsia
Similar endpoints
↥List of similar endpoints to
Functional dyspepsia
based on the number of shared cases.
Similar with more cases:
- Diseases of oesophagus, stomach and duodenum
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 84572 | 54528 | 29380 |
| Only index persons | 78993 | 51766 | 27227 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.30 | 1.56 | 0.82 |
| Only index persons | 1.61 | 1.90 | 1.04 |
| Median age at first event (years) | |||
| Whole population | 54.73 | 55.13 | 54.27 |
| Only index persons | 54.00 | 54.31 | 53.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10851 | 7440 | 3411 |
| Unadjusted period prevalence (%) | 2.54 | 2.92 | 1.71 |
| Median age at first event (years) | 55.01 | 53.20 | 58.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_FUNCDYSP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_FUNCDYSP | 1.076 [0.99, 1.17] | 0.083 |
| Birth year | 0.991 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 6595 out of 46692 females with K11_FUNCDYSP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_FUNCDYSP | 1.229 [1.13, 1.34] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 4612 out of 24579 males with K11_FUNCDYSP died.
Mortality risk
Mortality risk for people of age
years, who have K11_FUNCDYSP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.092% | 0.189% |
| 5 | 0.565% | 1.338% |
| 10 | 1.235% | 3.085% |
| 15 | 2.497% | 5.904% |
| 20 | 4.394% | 10.09% |
Relationships between endpoints
↥Index endpoint: K11_FUNCDYSP – Functional dyspepsia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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