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Perforation of oesophagus

DOID EFO Endpoint Browser PheWeb

K11_PERFOES

esophageal disease: A non-neoplastic or neoplastic disorder that affects the esophagus. Representative examples of non-neoplastic disorders include esophagitis and esophageal ulcer. Representative examples of neoplastic disorders include carcinomas, lymphomas, and melanomas.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K22.3
  • Hospital discharge: ICD-9 — 5304
  • Hospital discharge: ICD-8 — 5304
  • Cause of death: ICD-10 — K22.3
  • Cause of death: ICD-9 — 5304
  • Cause of death: ICD-8 — 5304

2 out of 7 registries used, show all original rules.

154

4. Check minimum number of events

None

154

5. Include endpoints

None

154

6. Filter based on genotype QC (FinnGen only)

144

Control definitions (FinnGen only)

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K22
Name in latin Perforatio oesophagi

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1531 568 942
Only index persons 1177 448 729
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.03
Only index persons 0.02 0.02 0.03
Median age at first event (years)
Whole population 65.20 69.78 62.30
Only index persons 64.77 68.22 62.65

-FinnGen-

Key figures

All Female Male
Number of individuals 144 52 92
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 63.43 61.24 64.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint K11_PERFOES and mortality.

Females

Parameter HR [95% CI] p-value
K11_PERFOES 2.851 [2.1, 3.87] < 0.001
Birth year 0.993 [0.98, 1.0] 0.097

During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 359 females with K11_PERFOES died.

Males

Parameter HR [95% CI] p-value
K11_PERFOES 3.71 [2.7, 5.09] < 0.001
Birth year 0.992 [0.98, 1.0] 0.097

During the follow-up period (1.1.1998 — 31.12.2019), 293 out of 605 males with K11_PERFOES died.

Mortality risk

Mortality risk for people of age

years, who have K11_PERFOES.

N-year risk Females Males
1 0.263% 0.671%
5 1.521% 4.559%
10 3.626% 11.643%
15 7.001% 21.535%
20 12.095% 35.304%

Relationships between endpoints

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Index endpoint: K11_PERFOES – Perforation of oesophagus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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