Barrett's esophagus: Esophageal lesion lined with columnar metaplastic epithelium which is flat or villiform. Barrett epithelium is characterized by two different types of cells: goblet cells and columnar cells. The symptomatology of Barrett esophagus is that of gastro-esophageal reflux. It is the precursor of most esophageal adenocarcinomas. (WHO)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1530 |
4. Check minimum number of eventsNone |
1530 |
5. Include endpointsNone |
1530 |
6. Filter based on genotype QC (FinnGen only) |
1486 |
Control definitions (FinnGen only)
Control exclude
K11_OESSTODUO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K22
Similar endpoints
↥List of similar endpoints to
Barrett oesophagus
based on the number of shared cases.
Similar with more cases:
- Diseases of oesophagus, stomach and duodenum
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9000 | 3115 | 5865 |
| Only index persons | 8584 | 2996 | 5588 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.09 | 0.16 |
| Only index persons | 0.18 | 0.11 | 0.21 |
| Median age at first event (years) | |||
| Whole population | 66.17 | 67.73 | 65.35 |
| Only index persons | 66.10 | 67.56 | 65.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1486 | 529 | 957 |
| Unadjusted period prevalence (%) | 0.38 | 0.21 | 0.48 |
| Median age at first event (years) | 65.98 | 66.43 | 65.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_BARRET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_BARRET | 1.414 [1.09, 1.83] | 0.008 |
| Birth year | 0.992 [0.98, 1.0] | 0.077 |
During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 2231 females with K11_BARRET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_BARRET | 1.55 [1.25, 1.92] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.039 |
During the follow-up period (1.1.1998 — 31.12.2019), 580 out of 4061 males with K11_BARRET died.
Mortality risk
Mortality risk for people of age
years, who have K11_BARRET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.313% |
| 5 | 0.75% | 1.877% |
| 10 | 1.949% | 5.046% |
| 15 | 3.682% | 9.446% |
| 20 | 6.433% | 16.279% |
Relationships between endpoints
↥Index endpoint: K11_BARRET – Barrett oesophagus
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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