gastric ulcer: An ulcerated lesion in the mucosal surface of the stomach. It may progress to involve the deeper layers of the gastric wall. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
9861 |
4. Check minimum number of eventsNone |
9861 |
5. Include endpoints |
11333 |
6. Filter based on genotype QC (FinnGen only) |
10872 |
Control definitions (FinnGen only)
Control exclude
K11_OESSTODUO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Gastroduodenal ulcer
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 128511 | 56186 | 70233 |
| Only index persons | 88186 | 39888 | 48298 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.81 | 1.61 | 1.96 |
| Only index persons | 1.67 | 1.47 | 1.84 |
| Median age at first event (years) | |||
| Whole population | 65.99 | 70.02 | 62.73 |
| Only index persons | 63.54 | 67.12 | 60.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10872 | 4226 | 6646 |
| Unadjusted period prevalence (%) | 2.69 | 1.66 | 3.34 |
| Median age at first event (years) | 63.11 | 61.52 | 64.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_GASTRODUOULC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_GASTRODUOULC | 1.847 [1.71, 2.0] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.49 |
During the follow-up period (1.1.1998 — 31.12.2019), 16688 out of 36076 females with K11_GASTRODUOULC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_GASTRODUOULC | 2.227 [2.04, 2.43] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 19500 out of 41459 males with K11_GASTRODUOULC died.
Mortality risk
Mortality risk for people of age
years, who have K11_GASTRODUOULC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.172% | 0.301% |
| 5 | 1.06% | 2.294% |
| 10 | 2.89% | 5.623% |
| 15 | 5.503% | 10.046% |
| 20 | 9.509% | 16.765% |
Relationships between endpoints
↥Index endpoint: K11_GASTRODUOULC – Gastroduodenal ulcer
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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