duodenal ulcer: An ulcer in the duodenal wall.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4293 |
4. Check minimum number of eventsNone |
4293 |
5. Include endpointsNone |
4293 |
6. Filter based on genotype QC (FinnGen only) |
4115 |
Control definitions (FinnGen only)
Control exclude
K11_OESSTODUO
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K20-K31
Name in latin
Ulcus duodeni
Similar endpoints
↥List of similar endpoints to
Duodenal ulcer
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
- Duodenal ulcer - Unspecified as acute or chronic, without haemorrhage or perforation, drug-induced
- Duodenal ulcer - Acute with haemorrhage, drug-induced
- Duodenal ulcer - Chronic without haemorrhage or perforation, drug-induced
- Duodenal ulcer - Acute without haemorrhage or perforation, drug-induced
- Duodenal ulcer - Chronic or unspecified with haemorrhage, drug-induced
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 53200 | 19840 | 32409 |
| Only index persons | 35730 | 13527 | 22203 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.78 | 0.57 | 0.91 |
| Only index persons | 0.71 | 0.50 | 0.85 |
| Median age at first event (years) | |||
| Whole population | 64.03 | 69.06 | 60.89 |
| Only index persons | 61.01 | 65.35 | 58.37 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4115 | 1236 | 2879 |
| Unadjusted period prevalence (%) | 1.16 | 0.49 | 1.45 |
| Median age at first event (years) | 61.29 | 58.99 | 62.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_DULC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_DULC | 1.947 [1.8, 2.11] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.174 |
During the follow-up period (1.1.1998 — 31.12.2019), 5182 out of 10940 females with K11_DULC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_DULC | 2.079 [1.91, 2.27] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 7428 out of 16631 males with K11_DULC died.
Mortality risk
Mortality risk for people of age
years, who have K11_DULC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.159% | 0.427% |
| 5 | 1.072% | 2.281% |
| 10 | 2.829% | 5.811% |
| 15 | 5.846% | 11.023% |
| 20 | 9.727% | 18.144% |
Relationships between endpoints
↥Index endpoint: K11_DULC – Duodenal ulcer
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data