Gastrojejunal ulcer

K11_GJULC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K28
  • Hospital discharge: ICD-9 534
  • Hospital discharge: ICD-8 534
  • Cause of death: ICD-10 K28
  • Cause of death: ICD-9 534
  • Cause of death: ICD-8 534

2 out of 7 registries used, show all original rules.

415

4. Check minimum number of events

None

415

5. Include endpoints

None

415

6. Filter based on genotype QC (FinnGen only)

404

Control definitions (FinnGen only)

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K20-K31
Name in latin Ulcus gastrojejunale

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4051 1650 2317
Only index persons 2697 1197 1500
Unadjusted period prevalence (%)
Whole population 0.06 0.05 0.06
Only index persons 0.05 0.04 0.06
Median age at first event (years)
Whole population 63.10 65.42 61.36
Only index persons 60.42 62.20 59.00

-FinnGen-

Key figures

All Female Male
Number of individuals 404 153 251
Unadjusted period prevalence (%) 0.10 0.06 0.13
Median age at first event (years) 62.36 58.78 64.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint K11_GJULC and mortality.

Females

Parameter HR [95% CI] p-value
K11_GJULC 1.998 [1.68, 2.37] < 0.001
Birth year 0.995 [0.98, 1.01] 0.344

During the follow-up period (1.1.1998 — 31.12.2019), 427 out of 1009 females with K11_GJULC died.

Males

Parameter HR [95% CI] p-value
K11_GJULC 2.506 [2.12, 2.97] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 659 out of 1313 males with K11_GJULC died.

Mortality risk

Mortality risk for people of age

years, who have K11_GJULC.

N-year risk Females Males
1 0.189% 0.51%
5 1.092% 2.866%
10 2.778% 7.0%
15 5.795% 12.272%
20 10.163% 20.428%

Relationships between endpoints

Index endpoint: K11_GJULC – Gastrojejunal ulcer

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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