gastric ulcer: An ulcerated lesion in the mucosal surface of the stomach. It may progress to involve the deeper layers of the gastric wall. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7306 |
4. Check minimum number of eventsNone |
7306 |
5. Include endpointsNone |
7306 |
6. Filter based on genotype QC (FinnGen only) |
7012 |
Control definitions (FinnGen only)
Control exclude
K11_OESSTODUO
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K20-K31
Name in latin
Ulcus ventriculi
Gastric ulcer
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 79346 | 37677 | 40471 |
| Only index persons | 55184 | 27139 | 28045 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.11 | 1.08 | 1.13 |
| Only index persons | 1.03 | 1.00 | 1.07 |
| Median age at first event (years) | |||
| Whole population | 67.72 | 71.07 | 64.58 |
| Only index persons | 65.73 | 68.63 | 62.93 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7012 | 3008 | 4004 |
| Unadjusted period prevalence (%) | 1.66 | 1.18 | 2.01 |
| Median age at first event (years) | 64.56 | 63.06 | 65.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_GULC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_GULC | 1.846 [1.71, 2.0] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.066 |
During the follow-up period (1.1.1998 — 31.12.2019), 12473 out of 26301 females with K11_GULC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_GULC | 2.282 [2.09, 2.49] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 13514 out of 27182 males with K11_GULC died.
Mortality risk
Mortality risk for people of age
years, who have K11_GULC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.127% | 0.506% |
| 5 | 1.019% | 2.634% |
| 10 | 2.509% | 6.965% |
| 15 | 4.779% | 13.105% |
| 20 | 8.269% | 21.443% |
Relationships between endpoints
↥Index endpoint: K11_GULC – Gastric ulcer
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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