atrophic gastritis: GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
11727 |
4. Check minimum number of eventsNone |
11727 |
5. Include endpointsNone |
11727 |
6. Filter based on genotype QC (FinnGen only) |
11226 |
Control definitions (FinnGen only)
Control exclude
K11_OESSTODUO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Chronic gastritis
based on the number of shared cases.
Similar with more cases:
- Diseases of oesophagus, stomach and duodenum
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 94876 | 54175 | 39802 |
| Only index persons | 79526 | 46950 | 32576 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.36 | 1.55 | 1.11 |
| Only index persons | 1.53 | 1.73 | 1.24 |
| Median age at first event (years) | |||
| Whole population | 65.45 | 66.05 | 64.60 |
| Only index persons | 64.03 | 64.35 | 63.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 11226 | 6266 | 4960 |
| Unadjusted period prevalence (%) | 2.47 | 2.46 | 2.49 |
| Median age at first event (years) | 62.13 | 59.90 | 64.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_CHRONGASTR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHRONGASTR | 1.223 [1.14, 1.31] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.109 |
During the follow-up period (1.1.1998 — 31.12.2019), 13654 out of 44907 females with K11_CHRONGASTR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHRONGASTR | 1.438 [1.33, 1.56] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 12030 out of 31653 males with K11_CHRONGASTR died.
Mortality risk
Mortality risk for people of age
years, who have K11_CHRONGASTR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.135% | 0.207% |
| 5 | 0.617% | 1.583% |
| 10 | 1.608% | 4.01% |
| 15 | 3.16% | 7.161% |
| 20 | 5.622% | 11.643% |
Relationships between endpoints
↥Index endpoint: K11_CHRONGASTR – Chronic gastritis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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