Alcoholic gastritis

K11_ALCGASTR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K29.2
  • Hospital discharge: ICD-9 5353A
  • Cause of death: ICD-10 K29.2
  • Cause of death: ICD-9 5353A

2 out of 7 registries used, show all original rules.

514

4. Check minimum number of events

None

514

5. Include endpoints

None

514

6. Filter based on genotype QC (FinnGen only)

499

Control definitions (FinnGen only)

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K29
Name in latin Gastritis acuta alcoholica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8819 1404 7278
Only index persons 5680 1039 4641
Unadjusted period prevalence (%)
Whole population 0.18 0.04 0.20
Only index persons 0.15 0.04 0.18
Median age at first event (years)
Whole population 45.44 47.43 44.92
Only index persons 45.25 47.33 44.79

-FinnGen-

Key figures

All Female Male
Number of individuals 499 99 400
Unadjusted period prevalence (%) 0.17 0.04 0.20
Median age at first event (years) 47.31 45.86 47.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint K11_ALCGASTR and mortality.

Females

Parameter HR [95% CI] p-value
K11_ALCGASTR 4.498 [3.58, 5.65] < 0.001
Birth year 0.993 [0.98, 1.0] 0.133

During the follow-up period (1.1.1998 — 31.12.2019), 319 out of 811 females with K11_ALCGASTR died.

Males

Parameter HR [95% CI] p-value
K11_ALCGASTR 5.276 [4.73, 5.89] < 0.001
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 1583 out of 3301 males with K11_ALCGASTR died.

Mortality risk

Mortality risk for people of age

years, who have K11_ALCGASTR.

N-year risk Females Males
1 0.401% 1.047%
5 2.604% 5.565%
10 5.726% 13.663%
15 11.178% 24.839%
20 19.69% 39.977%

Relationships between endpoints

Index endpoint: K11_ALCGASTR – Alcoholic gastritis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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