No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints
|
26929 |
6. Filter based on genotype QC (FinnGen only) |
26149 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Alcohol use disorder, Swedish definition
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 376626 | 96933 | 274361 |
| Only index persons | 275681 | 80653 | 195028 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.38 | 2.78 | 7.67 |
| Only index persons | 6.13 | 2.96 | 7.44 |
| Median age at first event (years) | |||
| Whole population | 44.42 | 43.19 | 44.72 |
| Only index persons | 43.03 | 41.61 | 43.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 26149 | 8171 | 17978 |
| Unadjusted period prevalence (%) | 7.21 | 3.21 | 9.03 |
| Median age at first event (years) | 45.35 | 40.35 | 47.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AUD_SWEDISH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AUD_SWEDISH | 4.447 [4.06, 4.87] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.174 |
During the follow-up period (1.1.1998 — 31.12.2019), 12942 out of 63056 females with AUD_SWEDISH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AUD_SWEDISH | 4.485 [4.12, 4.89] | < 0.001 |
| Birth year | 0.978 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 44989 out of 145712 males with AUD_SWEDISH died.
Mortality risk
Mortality risk for people of age
years, who have AUD_SWEDISH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.326% | 0.607% |
| 5 | 2.436% | 3.154% |
| 10 | 6.182% | 7.826% |
| 15 | 10.815% | 14.741% |
| 20 | 18.778% | 23.945% |
Relationships between endpoints
↥Index endpoint: AUD_SWEDISH – Alcohol use disorder, Swedish definition
GWS hits: 11
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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