epilepsy: A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
191 |
4. Check minimum number of eventsNone |
191 |
5. Include endpointsNone |
191 |
6. Filter based on genotype QC (FinnGen only) |
184 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G405
Name in latin
Ictus epileptici ex usu alcohol
Similar endpoints
↥List of similar endpoints to
Epileptic seizures related to alcohol
based on the number of shared cases.
Similar with more cases:
- Epilepsy
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
- Episodal and paroxysmal disorders
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3694 | 714 | 2952 |
| Only index persons | 2804 | 567 | 2237 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.02 | 0.08 |
| Only index persons | 0.07 | 0.02 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 51.19 | 51.05 | 51.18 |
| Only index persons | 51.40 | 51.11 | 51.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 184 | 39 | 145 |
| Unadjusted period prevalence (%) | 0.06 | 0.02 | 0.07 |
| Median age at first event (years) | 51.93 | 48.18 | 52.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint EPISEIZALCO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| EPISEIZALCO | 9.296 [7.52, 11.49] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.38 |
During the follow-up period (1.1.1998 — 31.12.2019), 231 out of 611 females with EPISEIZALCO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| EPISEIZALCO | 6.956 [6.12, 7.91] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1235 out of 2499 males with EPISEIZALCO died.
Mortality risk
Mortality risk for people of age
years, who have EPISEIZALCO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.35% | 1.289% |
| 5 | 5.042% | 6.949% |
| 10 | 12.988% | 16.759% |
| 15 | 22.412% | 29.851% |
| 20 | 38.968% | 47.135% |
Relationships between endpoints
↥Index endpoint: EPISEIZALCO – Epileptic seizures related to alcohol
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data