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Alcohol dependence

DOID EFO Endpoint Browser PheWeb

F5_ALCOHOL_DEPENDENCE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F10.2
  • Hospital discharge: ICD-9 — 303
  • Hospital discharge: ICD-8 — 303
  • Cause of death: ICD-10 — F10.2
  • Cause of death: ICD-9 — 303
  • Cause of death: ICD-8 — 303

2 out of 7 registries used, show all original rules.

11832

4. Check minimum number of events

None

11832

5. Include endpoints

None

11832

6. Filter based on genotype QC (FinnGen only)

11503

Control definitions (FinnGen only)

Control exclude F5_SUBSTANCE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3
Parent code in ICD-10 F10

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 173620 38412 132315
Only index persons 117725 30256 87469
Unadjusted period prevalence (%)
Whole population 3.11 1.10 3.70
Only index persons 2.77 1.11 3.34
Median age at first event (years)
Whole population 43.59 43.96 43.40
Only index persons 42.89 43.51 42.67

-FinnGen-

Key figures

All Female Male
Number of individuals 11503 3155 8348
Unadjusted period prevalence (%) 3.38 1.24 4.19
Median age at first event (years) 42.91 40.93 43.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_ALCOHOL_DEPENDENCE and mortality.

Females

Parameter HR [95% CI] p-value
F5_ALCOHOL_DEPENDENCE 6.146 [5.61, 6.74] < 0.001
Birth year 0.992 [0.98, 1.0] 0.04

During the follow-up period (1.1.1998 — 31.12.2019), 5482 out of 21848 females with F5_ALCOHOL_DEPENDENCE died.

Males

Parameter HR [95% CI] p-value
F5_ALCOHOL_DEPENDENCE 5.322 [4.88, 5.8] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 20503 out of 57066 males with F5_ALCOHOL_DEPENDENCE died.

Mortality risk

Mortality risk for people of age

years, who have F5_ALCOHOL_DEPENDENCE.

N-year risk Females Males
1 0.481% 0.763%
5 3.204% 4.845%
10 8.092% 12.409%
15 14.503% 23.095%
20 25.058% 37.095%

Relationships between endpoints

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Index endpoint: F5_ALCOHOL_DEPENDENCE – Alcohol dependence

GWS hits: 6

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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