≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Alcohol use disorder, ICD-based

EFO Endpoint Browser PheWeb

AUD

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F10.1, F10.2
  • Hospital discharge: ICD-9 — 303
  • Hospital discharge: ICD-8 — 303
  • Cause of death: ICD-10 — F10.1, F10.2
  • Cause of death: ICD-9 — 303
  • Cause of death: ICD-8 — 303

2 out of 7 registries used, show all original rules.

19245

4. Check minimum number of events

None

19245

5. Include endpoints

None

19245

6. Filter based on genotype QC (FinnGen only)

18695

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 263725 67743 192653
Only index persons 199840 58053 141787
Unadjusted period prevalence (%)
Whole population 4.47 1.94 5.38
Only index persons 4.46 2.13 5.41
Median age at first event (years)
Whole population 44.24 43.33 44.49
Only index persons 43.51 42.51 43.92

-FinnGen-

Key figures

All Female Male
Number of individuals 18695 5983 12712
Unadjusted period prevalence (%) 5.09 2.35 6.38
Median age at first event (years) 44.77 40.88 46.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint AUD and mortality.

Females

Parameter HR [95% CI] p-value
AUD 4.662 [4.22, 5.15] < 0.001
Birth year 0.993 [0.99, 1.0] 0.109

During the follow-up period (1.1.1998 — 31.12.2019), 9516 out of 47066 females with AUD died.

Males

Parameter HR [95% CI] p-value
AUD 4.702 [4.31, 5.13] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 34964 out of 108516 males with AUD died.

Mortality risk

Mortality risk for people of age

years, who have AUD.

N-year risk Females Males
1 0.404% 0.637%
5 2.481% 4.134%
10 5.84% 9.669%
15 11.189% 17.983%
20 19.637% 29.174%

Relationships between endpoints

↥

Index endpoint: AUD – Alcohol use disorder, ICD-based

GWS hits: 10

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data