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Substance abuse

Endpoint Browser PheWeb

KRA_PSY_SUBSTANCE_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F10-F19
  • Hospital discharge: ICD-9 — 29[1-2]|30[3-5]
  • Hospital discharge: ICD-8 — 291|30[3-4]
  • Hospital discharge: excluded ICD-10 — F10.0
  • Hospital discharge: excluded ICD-9 — 3050A
  • Cause of death: ICD-10 — F10-F19
  • Cause of death: ICD-9 — 29[1-2]|30[3-5]
  • Cause of death: ICD-8 — 291|30[3-4]

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 402168 113244 284097
Only index persons 303852 97092 206760
Unadjusted period prevalence (%)
Whole population 6.58 3.24 7.94
Only index persons 6.51 3.57 7.89
Median age at first event (years)
Whole population 43.02 41.93 43.34
Only index persons 41.43 40.24 42.00

-FinnGen-

Key figures

All Female Male
Number of individuals 27791 10033 17758
Unadjusted period prevalence (%) 7.12 3.94 8.92
Median age at first event (years) 44.92 40.73 47.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_SUBSTANCE_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_SUBSTANCE_EXMORE 4.061 [3.67, 4.49] < 0.001
Birth year 0.992 [0.98, 1.0] 0.056

During the follow-up period (1.1.1998 — 31.12.2019), 13786 out of 77466 females with KRA_PSY_SUBSTANCE_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_SUBSTANCE_EXMORE 4.208 [3.85, 4.6] < 0.001
Birth year 0.981 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 43549 out of 155699 males with KRA_PSY_SUBSTANCE_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_SUBSTANCE_EXMORE.

N-year risk Females Males
1 0.208% 0.543%
5 1.851% 3.455%
10 4.919% 8.802%
15 9.826% 16.395%
20 16.39% 26.633%

Relationships between endpoints

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Index endpoint: KRA_PSY_SUBSTANCE_EXMORE – Substance abuse

GWS hits: 18

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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